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Pharmacologic Treatments for Acute Respiratory Distress Syndrome.

ABSTRACT: Acute respiratory distress syndrome is a heterogenous syndrome with many etiologies for which there are no definitive pharmacologic treatments, despite decades of research. We explore some adjunctive pharmacologic therapies, including neuromuscular blockade, corticosteroids, and inhaled pulmonary vasodilators. Additionally, we explore some investigative therapies, including Vitamin C, beta-agonists, statins, mesenchymal stromal cells, and granulocyte-macrophage colony stimulating factor. We do discuss the potential role of steroids in acute respiratory distress syndrome with severe acute respiratory syndrome coronavirus 2 as a trigger. The standard of care, however, remains supportive care.

SUBMITTER: Qadir N

PROVIDER: S-EPMC8449143 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Pharmacologic Treatments for Acute Respiratory Distress Syndrome.

Qadir Nida N Chang Steven Y SY

Critical care clinics 20211001 4

Acute respiratory distress syndrome is a heterogenous syndrome with many etiologies for which there are no definitive pharmacologic treatments, despite decades of research. We explore some adjunctive pharmacologic therapies, including neuromuscular blockade, corticosteroids, and inhaled pulmonary vasodilators. Additionally, we explore some investigative therapies, including Vitamin C, beta-agonists, statins, mesenchymal stromal cells, and granulocyte-macrophage colony stimulating factor. We do d ...[more]

PMID: 34548139

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