Characteristics and Research Waste Among Randomized Clinical Trials in Gastric Cancer.

ABSTRACT:

Importance

The results of numerous large randomized clinical trials (RCTs) have changed clinical practice in gastric cancer (GC). However, research waste (ie, unpublished data, inadequate reporting, or avoidable design limitations) is still a major challenge for evidence-based medicine.

Objectives

To determine the characteristics of GC RCTs in the past 20 years and the presence of research waste and to explore potential targets for improvement.

Design, setting, and participants

In this cross-sectional study of GC RCTs, ClinicalTrials.gov was searched for phase 3 or 4 RCTs registered from January 2000 to December 2019 using the keyword gastric cancer. Independent investigators undertook assessments and resolved discrepancies via consensus. Data were analyzed from Augus

SUBMITTER: Lu J 

PROVIDER: S-EPMC8449283 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature