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CREBA and CREBB in two identified neurons gate long-term memory formation in Drosophila.


ABSTRACT: Episodic events are frequently consolidated into labile memory but are not necessarily transferred to persistent long-term memory (LTM). Regulatory mechanisms leading to LTM formation are poorly understood, however, especially at the resolution of identified neurons. Here, we demonstrate enhanced LTM following aversive olfactory conditioning in Drosophila when the transcription factor cyclic AMP response element binding protein A (CREBA) is induced in just two dorsal-anterior-lateral (DAL) neurons. Our experiments show that this process is regulated by protein-gene interactions in DAL neurons: (1) crebA transcription is induced by training and repressed by crebB overexpression, (2) CREBA bidirectionally modulates LTM formation, (3) crebA overexpression enhances training-induced gene transcription, and (4) increasing membrane excitability enhances LTM formation and gene expression. These findings suggest that activity-dependent gene expression in DAL neurons during LTM formation is regulated by CREB proteins.

SUBMITTER: Lin HW 

PROVIDER: S-EPMC8449312 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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CREBA and CREBB in two identified neurons gate long-term memory formation in <i>Drosophila</i>.

Lin Hsuan-Wen HW   Chen Chun-Chao CC   de Belle J Steven JS   Tully Tim T   Chiang Ann-Shyn AS  

Proceedings of the National Academy of Sciences of the United States of America 20210901 37


Episodic events are frequently consolidated into labile memory but are not necessarily transferred to persistent long-term memory (LTM). Regulatory mechanisms leading to LTM formation are poorly understood, however, especially at the resolution of identified neurons. Here, we demonstrate enhanced LTM following aversive olfactory conditioning in <i>Drosophila</i> when the transcription factor cyclic AMP response element binding protein A (CREBA) is induced in just two dorsal-anterior-lateral (DAL  ...[more]

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