Ontology highlight
ABSTRACT:
SUBMITTER: Llabata P
PROVIDER: S-EPMC8449313 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Llabata Paula P Torres-Diz Manuel M Gomez Antonio A Tomas-Daza Laureano L Romero Octavio A OA Grego-Bessa Joaquim J Llinas-Arias Pere P Valencia Alfonso A Esteller Manel M Javierre Biola M BM Zhang Xiaoyang X Sanchez-Cespedes Montse M
Proceedings of the National Academy of Sciences of the United States of America 20210901 37
The MYC axis is disrupted in cancer, predominantly through activation of the MYC family oncogenes but also through inactivation of the MYC partner MAX or of the MAX partner MGA. MGA and MAX are also members of the polycomb repressive complex, ncPRC1.6. Here, we use genetically modified MAX-deficient small-cell lung cancer (SCLC) cells and carry out genome-wide and proteomics analyses to study the tumor suppressor function of MAX. We find that MAX mutant SCLCs have ASCL1 or NEUROD1 or combined AS ...[more]