Ontology highlight
ABSTRACT:
SUBMITTER: Mathes S
PROVIDER: S-EPMC8449320 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Mathes Sebastian S Fahrner Alexandra A Ghoshdastider Umesh U Rüdiger Hannes A HA Leunig Michael M Wolfrum Christian C Krützfeldt Jan J
Proceedings of the National Academy of Sciences of the United States of America 20210901 37
Aged skeletal muscle is markedly affected by fatty muscle infiltration, and strategies to reduce the occurrence of intramuscular adipocytes are urgently needed. Here, we show that fibroblast growth factor-2 (FGF-2) not only stimulates muscle growth but also promotes intramuscular adipogenesis. Using multiple screening assays upstream and downstream of microRNA (miR)-29a signaling, we located the secreted protein and adipogenic inhibitor SPARC to an FGF-2 signaling pathway that is conserved betwe ...[more]