Intrinsic physicochemical profile of marketed antibody-based biotherapeutics.

ABSTRACT: Feeding biopharma pipelines with biotherapeutic candidates that possess desirable developability profiles can help improve the productivity of biologic drug discovery and development. Here, we have derived an in silico profile by analyzing computed physicochemical descriptors for the variable regions (Fv) found in 77 marketed antibody-based biotherapeutics. Fv regions of these biotherapeutics demonstrate significant diversities in their germlines, complementarity determining region loop lengths, hydrophobicity, and charge distributions. Furthermore, an analysis of 24 physicochemical descriptors, calculated using homology-based molecular models, has yielded five nonredundant descriptors whose distributions represent stability, isoelectric point, and molecular surface characteristics of thei

SUBMITTER: Ahmed L 

PROVIDER: S-EPMC8449350 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature