Blood pressure, executive function, and network connectivity in middle-aged adults at risk of dementia in late life.

ABSTRACT: Midlife blood pressure is associated with structural brain changes, cognitive decline, and dementia in late life. However, the relationship between early adulthood blood pressure exposure, brain structure and function, and cognitive performance in midlife is not known. A better understanding of these relationships in the preclinical stage may advance our mechanistic understanding of vascular contributions to late-life cognitive decline and dementia and may provide early therapeutic targets. To identify resting-state functional connectivity of executive control networks (ECNs), a group independent components analysis was performed of functional MRI scans of 600 individuals from the Coronary Artery Risk Development in Young Adults longitudinal cohort study, with cumulative systolic blood pre

SUBMITTER: Jenkins LM 

PROVIDER: S-EPMC8449402 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature