NAD⁺ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING.

ABSTRACT: Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disorder. Impaired neuronal bioenergetics and neuroinflammation are thought to play key roles in the progression of AD, but their interplay is not clear. Nicotinamide adenine dinucleotide (NAD⁺) is an important metabolite in all human cells in which it is pivotal for multiple processes including DNA repair and mitophagy, both of which are impaired in AD neurons. Here, we report that levels of NAD⁺ are reduced and markers of inflammation increased in the brains of APP/PS1 mutant transgenic mice with beta-amyloid pathology. Treatment of APP/PS1 mutant mice with the NAD⁺ precursor nicotinamide riboside (NR) for 5 mo increased brain NAD⁺ levels, reduced expression of proinflammator

SUBMITTER: Hou Y 

PROVIDER: S-EPMC8449423 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature