Sequencing refractory regions in bird genomes are hotspots for accelerated protein evolution.

ABSTRACT:

Background

Approximately 1000 protein encoding genes common for vertebrates are still unannotated in avian genomes. Are these genes evolutionary lost or are they not yet found for technical reasons? Using genome landscapes as a tool to visualize large-scale regional effects of genome evolution, we reexamined this question.

Results

On basis of gene annotation in non-avian vertebrate genomes, we established a list of 15,135 common vertebrate genes. Of these, 1026 were not found in any of eight examined bird genomes. Visualizing regional genome effects by our sliding window approach showed that the majority of these "missing" genes can be clustered to 14 regions of the human reference genome. In these clusters, an additional 1517 genes (often gene fragments) were underrepresent

SUBMITTER: Huttener R 

PROVIDER: S-EPMC8449477 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature