Pediatric hemophagocytic lymphohistiocytosis: A rarely diagnosed entity in a developing country.

ABSTRACT:

Background

Hemophagocytic lymphohistiocytosis (HLH) is an exaggerated inflammatory reaction secondary to a host's inadequate immune response causing a self-perpetuating loop of altered regulation. Signs and symptoms of HLH are compatible with other common diseases and are nonspecific. Underdiagnosis makes it difficult to estimate the real incidence of HLH, especially in developing countries.

Methods

Retrospective, descriptive study of pediatric patients admitted to a high-complexity institution in Cali, Colombia between 2012 and 2019 with HLH diagnosis. Medical history review to complete an electronic database and a secondary, descriptive analysis was carried out. The study was approved by the Institutional Ethics Committee.

Results

Twenty-one patients were included.

SUBMITTER: Cleves D 

PROVIDER: S-EPMC8449481 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature