DELEAT: gene essentiality prediction and deletion design for bacterial genome reduction.

ABSTRACT:

Background

The study of gene essentiality is fundamental to understand the basic principles of life, as well as for applications in many fields. In recent decades, dozens of sets of essential genes have been determined using different experimental and bioinformatics approaches, and this information has been useful for genome reduction of model organisms. Multiple in silico strategies have been developed to predict gene essentiality, but no optimal algorithm or set of gene features has been found yet, especially for non-model organisms with incomplete functional annotation.

Results

We have developed DELEAT v0.1 (DELetion design by Essentiality Analysis Tool), an easy-to-use bioinformatic tool which integrates an in silico gene essentiality classifier in a pipeline allowing au

SUBMITTER: Solana J 

PROVIDER: S-EPMC8449488 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature