Fever during pregnancy as a risk factor for neurodevelopmental disorders: results from a systematic review and meta-analysis.

ABSTRACT:

Background

Fever during pregnancy is a relatively common and most often trivial event. However, under specific conditions, it could affect significantly fetal brain development. Few studies, with inconsistent results, investigated whether fever, regardless the pathogen, could represent a risk factor for neurodevelopmental disorders (NDD) in the offspring. We aimed to explore further this question by performing a systematic review and meta-analysis.

Methods

Peer-reviewed studies exploring the occurrence of NDD in offspring after a fetal exposure to maternal fever were included. We specifically considered the impact of fever severity and duration, taking into consideration some confounding variables such as the use of antipyretic during pregnancy, the trimester in which the fe

SUBMITTER: Antoun S 

PROVIDER: S-EPMC8449704 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature