B7-H5 blockade enhances CD8⁺ T-cell-mediated antitumor immunity in colorectal cancer.

ABSTRACT: Negative immune checkpoint blockade immunotherapy has shown potential for multiple malignancies including colorectal cancer (CRC). B7-H5, a novel negative immune checkpoint regulator, is highly expressed in tumor tissues and promotes tumor immune escape. However, the clinical significance of B7-H5 expression in CRC and the role of B7-H5 in the tumor microenvironment (TME) has not been fully clarified. In this study, we observed that high B7-H5 expression in CRC tissues was significantly correlated with the lymph node involvement, AJCC stage, and survival of CRC patients. A significant inverse correlation was also observed between B7-H5 expression and CD8⁺ T-cell infiltration in CRC tissues. Kaplan-Meier analysis showed that patients with high B7-H5 expression and low CD8^+</

SUBMITTER: Wang J 

PROVIDER: S-EPMC8449782 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature