Effect of moderate potassium-elevating treatment in long QT syndrome: the TriQarr Potassium Study.

ABSTRACT:

Background

In long QT syndrome (LQTS), beta blockers prevent arrhythmias. As a supplement, means to increase potassium has been suggested. We set to investigate the effect of moderate potassium elevation on cardiac repolarisation.

Methods

Patients with LQTS with a disease-causing KCNQ1 or KCNH2 variant were included. In addition to usual beta-blocker treatment, patients were prescribed (1) 50 mg spironolactone (low dose) or (2) 100 mg spironolactone and 3 g potassium chloride per day (high dose+). Electrocardiographic measures were obtained at baseline and after 7 days of treatment.

Results

Twenty patients were enrolled (10 low dose and 10 high dose+). One patient was excluded due to severe influenza-like symptoms, and 5 of 19 patients comp

SUBMITTER: Marstrand P 

PROVIDER: S-EPMC8449979 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature