A simple model explains the cell cycle-dependent assembly of centromeric nucleosomes in holocentric species.

ABSTRACT: Centromeres are essential for chromosome movement. In independent taxa, species with holocentric chromosomes exist. In contrast to monocentric species, where no obvious dispersion of centromeres occurs during interphase, the organization of holocentromeres differs between condensed and decondensed chromosomes. During interphase, centromeres are dispersed into a large number of CENH3-positive nucleosome clusters in a number of holocentric species. With the onset of chromosome condensation, the centromeric nucleosomes join and form line-like holocentromeres. Using polymer simulations, we propose a mechanism relying on the interaction between centromeric nucleosomes and structural maintenance of chromosomes (SMC) proteins. Different sets of molecular dynamic simulations were evaluated by test

SUBMITTER: Camara AS 

PROVIDER: S-EPMC8450114 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature