Aptamer-mediated synthesis of multifunctional nano-hydroxyapatite for active tumour bioimaging and treatment.

ABSTRACT:

Objectives

The nano-hydroxyapatite (nHAp) is widely used to develop imaging probes and drug carriers due to its excellent bioactivity and biocompatibility. However, traditional methods usually need cumbersome and stringent conditions such as high temperature and post-modification to prepare the functionalized nHAp, which do not benefit the particles to enter cells due to the increased particle size. Herein, a biomimetic synthesis strategy was explored to achieve the AS1411-targeted tumour dual-model bioimaging using DNA aptamer AS1411 as a template. Then, the imaging properties and the biocompatibility of the synthesized AS-nFAp:Gd/Tb were further investigated.

Materials and methods

The AS-nFAp:Gd/Tb was prepared under mild conditions through a one-pot procedure with AS1411

SUBMITTER: Zhang W 

PROVIDER: S-EPMC8450118 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature