Initial mechanical conditions within an optimized bone scaffold do not ensure bone regeneration - an in silico analysis.

ABSTRACT: Large bone defects remain a clinical challenge because they do not heal spontaneously. 3-D printed scaffolds are a promising treatment option for such critical defects. Recent scaffold design strategies have made use of computer modelling techniques to optimize scaffold design. In particular, scaffold geometries have been optimized to avoid mechanical failure and recently also to provide a distinct mechanical stimulation to cells within the scaffold pores. This way, mechanical strain levels are optimized to favour the bone tissue formation. However, bone regeneration is a highly dynamic process where the mechanical conditions immediately after surgery might not ensure optimal regeneration throughout healing. Here, we investigated in silico whether scaffolds presenting optimal mechanical co

SUBMITTER: Perier-Metz C 

PROVIDER: S-EPMC8450217 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature