Characterisation of SARS-CoV-2 clades based on signature SNPs unveils continuous evolution.

ABSTRACT: Since the emergence of SARS-CoV-2 in Wuhan, China more than a year ago, it has spread across the world in a very short span of time. Although, different forms of vaccines are being rolled out for vaccination programs around the globe, the mutation of the virus is still a cause of concern among the research communities. Hence, it is important to study the constantly evolving virus and its strains in order to provide a much more stable form of cure. This fact motivated us to conduct this research where we have initially carried out multiple sequence alignment of 15359 and 3033 global dataset without Indian and the dataset of exclusive Indian SARS-CoV-2 genomes respectively, using MAFFT. Subsequently, phylogenetic analyses are performed using Nextstrain to identify virus clades. Consequently,

SUBMITTER: Ghosh N 

PROVIDER: S-EPMC8450220 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature