Effect of iron supplementation in patients with heart failure and iron deficiency: A systematic review and meta-analysis.

ABSTRACT:

Background

The effectiveness of oral and intravenous iron supplementation in reducing the risk of mortality and hospitalizations in HF patients with iron deficiency is not well-established.

Methods

A thorough literature search was conducted across 2 electronic databases (Medline and Cochrane Central) from inception through March 2021. RCTs assessing the impact of iron supplementation on clinical outcomes in iron deficient HF patients were considered for inclusion. Primary end-points included all-cause mortality and HF hospitalization. Evaluations were reported as odds ratios (ORs) or risk ratios (RRs) with 95% confidence intervals (CI) and analysis was performed using a random effects model. I² index was used to assess heterogeneity.

Results

From the 2599 a

SUBMITTER: Yamani N 

PROVIDER: S-EPMC8450242 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature