Loss of chemerin triggers bone remodeling in vivo and in vitro.

ABSTRACT:

Objective

It was reported that chemerin as an adipocyte-secreted protein could regulate bone resorption and bone formation. However, the specific molecular and gene mechanism of the chemerin role is unclear. The aim of this study is to evaluate the role of chemerin in bone metabolism.

Methods

In the present study, we investigated the effects of chemerin on bone remodeling in rarres2 knockout (Rarres2^-/-) mice and examined the role of chemerin as a determinant of osteoblast and osteoclast differentiation in Mc3t3-E1 and Raw264.7 cell lines.

Results

The results showed that the bone mineral density and volume score, trabecular thickness, weight and bone formation marker BALP increased, but Tb.Sp and bone resorption marker TRACP-5b decreased in Rarres2^-/-<

SUBMITTER: Han L 

PROVIDER: S-EPMC8450264 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature