Antibodies to Both Ro52 and Ro60 for Identifying Sjogren's Syndrome Patients Best Suited for Clinical Trials of Disease-Modifying Therapies.

ABSTRACT:

Objective

To assess anti-Ro52 and anti-Ro60 serologic profiles as markers of clinically relevant phenotypic subsets of patients with Sjögren's syndrome (SS).

Methods

From a cohort of 839 consecutive patients with suspected or established SS seen in our multidisciplinary SS center, we compared the association of key phenotypic features in 390 patients who fulfilled SS classification criteria and in the parent cohort, stratifed by the presence of both anti-Ro60 and anti-Ro52, anti-Ro60 alone, and anti-Ro52 alone.

Results

The SS cohort included 227 patients (58%) with both anti-Ro60 and anti-Ro52, 65 (17%) with anti-Ro60 alone, 58 (15%) with anti-Ro52 alone, and 40 (10%) with neither antibody. Those with both anti-Ro60 and anti-Ro52 had a significantly increased prevalen

SUBMITTER: Armagan B 

PROVIDER: S-EPMC8450300 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature