IFNβ Is a Potent Adjuvant for Cancer Vaccination Strategies.

ABSTRACT: Cancer vaccination drives the generation of anti-tumor T cell immunity and can be enhanced by the inclusion of effective immune adjuvants such as type I interferons (IFNs). Whilst type I IFNs have been shown to promote cross-priming of T cells, the role of individual subtypes remains unclear. Here we systematically compared the capacity of distinct type I IFN subtypes to enhance T cell responses to a whole-cell vaccination strategy in a pre-clinical murine model. We show that vaccination in combination with IFNβ induces significantly greater expansion of tumor-specific CD8⁺ T cells than the other type I IFN subtypes tested. Optimal expansion was dependent on the presence of XCR1⁺ dendritic cells, CD4⁺ T cells, and CD40/CD40L signaling. Therapeutically, vacc

SUBMITTER: Audsley KM 

PROVIDER: S-EPMC8450325 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature