Development of a novel label-free all-fiber optofluidic biosensor based on Fresnel reflection and its applications.

ABSTRACT: A novel, compact, cost-effective, and robust label-free all-fiber optofluidic biosensor (LF-AOB) based on Fresnel reflection mechanism was built through integrating single-multi mode fiber coupler and highly sensitive micro-photodetector. The Fresnel reflection light intensity detected by the LF-AOB greatly depended on the RI change on the end-surface of the fiber probe according to experimental and simulation results. The capability of the LF-AOB for real-time in situ detection in optofluidic system were verified by measuring salt and protein solution, and the lowest limit of detection was 1.0 × 10^-6 RIU. Our proposed theory can effectively eliminate the influence of light intensity fluctuation, and one-point calibration method of sensor performance is conducive for rapid and c

SUBMITTER: Xu W 

PROVIDER: S-EPMC8450429 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature