Construction and Validation of a Novel Immunosignature for Overall Survival in Uveal Melanoma.

ABSTRACT:

Objectives

Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, and immune infiltration plays a crucial role in the prognosis of UM. This study aimed to generate an immunological marker-based predictive signature for the overall survival (OS) of UM patients.

Methods

Single-sample gene-set enrichment analysis (ssGSEA) was used to profile immune cell infiltration in 79 patients with UM from The Cancer Genome Atlas (TCGA) database. Univariate and multivariate least absolute shrinkage and selection operator (LASSO) Cox regressions were used to determine the prognostic factors for UM and construct the predictive immunosignature. Receiver operating characteristic (ROC) curves, decision curve analysis (DCA), and calibration curves were performed to evalu

SUBMITTER: Gu C 

PROVIDER: S-EPMC8450517 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature