Central and peripheral pathogenetic forms of type 2 diabetes: a proof-of-concept study.

ABSTRACT:

Hypothesis

Previous studies provide evidence that glycated haemoglobin (HbA1c) and fasting plasma glucose (FPG) should not be considered as interchangeable alternatives in the diagnosis of the same type 2 diabetes, but as indicators of its different pathogenetic subtypes. This study was conducted to determine whether a particularly high amount of glucose in either HbA1c form or in fasting plasma would be found in diabetic patients genetically predisposed for either intensive cognitive or intensive muscle metabolic activity, respectively.

Methods

HbA1c and FPG levels, polymorphisms of genes indicating the predisposition to different cognitive activity (the dopamine D2 receptor (DRD2/ANKK1)), muscle activity (peroxisome proliferator-activated receptor gamma, coactivator 1 alph

SUBMITTER: Davydov DM 

PROVIDER: S-EPMC8450667 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature