Three-dimensional microengineered vascularised endometrium-on-a-chip.

ABSTRACT:

Study question

Can we reconstitute physiologically relevant 3-dimensional (3D) microengineered endometrium in-vitro model?

Summary answer

Our representative microengineered vascularised endometrium on-a-chip closely recapitulates the endometrial microenvironment that consists of three distinct layers including epithelial cells, stromal fibroblasts and endothelial cells in a 3D extracellular matrix in a spatiotemporal manner.

What is known already

Organ-on-a-chip, a multi-channel 3D microfluidic cell culture system, is widely used to investigate physiologically relevant responses of organ systems.

Study design, size, duration

The device consists of five microchannels that are arrayed in parallel and partitioned by array of micropost. Two central channels are for

SUBMITTER: Ahn J 

PROVIDER: S-EPMC8450871 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature