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Isolation and characterization of new phenolic siderophores with antimicrobial properties from Pseudomonas sp. UIAU-6B.

ABSTRACT: Five new phenolic siderophores 1-5 were isolated from the organic extract of a culture broth in a modified SGG medium of Pseudomonas sp. UIAU-6B, obtained from sediments collected from the Oyun river in North Central Nigeria. The structure of the new compounds, pseudomonin A-C (1-3) and pseudomobactin A and B (4 and 5) isolated alongside two known compounds, pseudomonine (6) and salicylic acid (7), were elucidated based on high-resolution mass spectrometry, 1D and 2D NMR analyses. The absolute configuration of the threonine residue in compounds 1-5 was determined by Marfey analysis. The antimicrobial evaluation of compound 4 exhibited the most potent activity against vancomycin-sensitive Enterococcus faecium VS144754, followed by 3 and 5, with MIC values ranging from 8 to 32 µg/mL. Compounds 2 and 3 exhibited moderate activity against Mycobacterium tuberculosis H37Rv, with MIC values of 7.8 and 15.6 µg/mL, respectively. Plausible biosynthetic hypotheses toward the new compounds 1-5 were proposed.

SUBMITTER: Oluwabusola ET 

PROVIDER: S-EPMC8450953 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Isolation and characterization of new phenolic siderophores with antimicrobial properties from <i>Pseudomonas</i> sp. UIAU-6B.

Oluwabusola Emmanuel Tope ET   Adebisi Olusoji O OO   Reyes Fernando F   Acquah Kojo S KS   De La Cruz Mercedes M   Mweetwa Larry L LL   Rajakulendran Joy E JE   Warner Digby F DF   Hai Deng D   Ebel Rainer R   Jaspars Marcel M  

Beilstein journal of organic chemistry 20210913

Five new phenolic siderophores <b>1</b>-<b>5</b> were isolated from the organic extract of a culture broth in a modified SGG medium of <i>Pseudomonas</i> sp. UIAU-6B, obtained from sediments collected from the Oyun river in North Central Nigeria. The structure of the new compounds, pseudomonin A-C (<b>1</b>-<b>3</b>) and pseudomobactin A and B (<b>4</b> and <b>5</b>) isolated alongside two known compounds, pseudomonine (<b>6</b>) and salicylic acid (<b>7</b>), were elucidated based on high-resol  ...[more]

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