Synthesis and antimicrobial activity of 1H-1,2,3-triazole and carboxylate analogues of metronidazole.

ABSTRACT: Herein, a series of novel 1H-1,2,3-triazole and carboxylate derivatives of metronidazole (5a-i and 7a-e) were synthesized and evaluated for their antimicrobial activity in vitro. All the newly synthesized compounds were characterized by ¹H NMR, ¹³C NMR, HRMS, and ¹⁹F NMR (5b, 5c and 5h) spectroscopy wherever applicable. The structures of compounds 3, 5c and 7b were unambiguously confirmed by single crystal X-ray analysis diffraction method. Single crystal X-ray structure analysis supported the formation of the metronidazole derivatives. The antimicrobial (antifungal and antibacterial) activity of the prepared compounds was studied. All compounds (except 2 and 3) showed a potent inh

SUBMITTER: Avula SK 

PROVIDER: S-EPMC8450958 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature