Preventing Alzheimer's disease within reach by 2025: Targeted-risk-AD-prevention (TRAP) strategy.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is a progressive neurodegenerative disease that currently affects 6.2 million people in the United States and is projected to impact 12.7 million worldwide in 2050 with no effective disease-modifying therapeutic or cure. In 2011 as part of the National Alzheimer's Project Act, the National Plan to Address Alzheimer's Disease was signed into law which proposed to effectively prevent AD by 2025, which is rapidly approaching. The preclinical phase of AD can begin 20 years prior to diagnosis, which provides an extended window for preventive measures that would exert a transformative impact on incidence and prevalence of AD.

Methods

A novel combination of text-mining and natural language processing strategies to identify (1) AD risk factors,

SUBMITTER: Vitali F 

PROVIDER: S-EPMC8451031 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature