Comorbid Major Depressive Disorder in Schizophrenia: A Systematic Review and Meta-Analysis.

ABSTRACT: Comorbid major depressive disorder (MDD) in schizophrenia (SZ; SZ-MDD) has been identified as a major prognostic factor. However, the prevalence and associated factors of SZ-MDD have never been explored in a meta-analysis. All studies assessing the prevalence of SZ-MDD in stabilized outpatients with a standardized scale or with structured interviews were included. The Medline, Web of Science, PsycINFO, and Google Scholar databases were searched. Using random effects models, we calculated the pooled estimate of the prevalence of SZ-MDD. We used meta-regression and subgroup analyses to evaluate the potential moderators of the prevalence estimates, and we used the leave-one-out method for sensitivity analyses. Of the 5633 potentially eligible studies identified, 18 studies (n = 6140 SZ stabil

SUBMITTER: Etchecopar-Etchart D 

PROVIDER: S-EPMC8451068 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature