Size-adjusted aortic valve area: refining the definition of severe aortic stenosis.

ABSTRACT:

Aims

Severe aortic valve stenosis (AS) is defined by an aortic valve area (AVA) <1 cm2 or an AVA indexed to body surface area (BSA) <0.6 cm/m2, despite little evidence supporting the latter approach and important intrinsic limitations of BSA indexation. We hypothesized that AVA indexed to height (H) might be more applicable to a wide range of populations and body morphologies and might provide a better predictive accuracy.

Methods and results

In 1298 patients with degenerative AS and preserved ejection fraction from three different countries and continents (derivation cohort), we aimed to establish an AVA/H threshold that would be equivalent to 1.0 cm2 for defining severe AS. In a distinct prospective validation cohort of 395 patients, we compared the predictive accuracy of

SUBMITTER: Vulesevic B 

PROVIDER: S-EPMC8451205 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature