Transarterial Embolization of Liver Cancer in a Transgenic Pig Model.

ABSTRACT:

Purpose

To develop and characterize a porcine model of liver cancer that could be used to test new locoregional therapies.

Materials and methods

Liver tumors were induced in 18 Oncopigs (transgenic pigs with Cre-inducible TP53^R167H and KRAS^G12D mutations) by using an adenoviral vector encoding the Cre-recombinase gene. The resulting 60 tumors were characterized on multiphase contrast-enhanced CT, angiography, perfusion, micro-CT, and necropsy. Transarterial embolization was performed using 40-120 μm (4 pigs) or 100-300 μm (4 pigs) Embosphere microspheres. Response to embolization was evaluated on imaging. Complications were determined based on daily clinical evaluation, laboratory results, imaging, and necropsy.

Results

Liver tumors developed at

SUBMITTER: Nurili F 

PROVIDER: S-EPMC8451249 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature