PROState Pathway Embedded Comparative Trial: The IP3-PROSPECT study.

ABSTRACT:

Introduction

The traditional double blind RCT is the 'gold standard' trial design. For a variety of reasons, these designs often fail to accrue enough participants to conclude. This is particularly challenging in localized prostate cancer. The cohort multiple randomised controlled trial (cmRCT) trial design may represent an alternative approach to delivering robust comparative data in prostate cancer.

Patients and methods

IP3-PROSPECT is a cmRCT designed to test multiple prostate cancer interventions from eligible men in one cohort. Key to the design is two points of consent. First, at point of consent one, men referred for prostate cancer investigations are invited to join the cohort. They may then be randomly invited at a later date to consider an intervention at point of

SUBMITTER: Bass EJ 

PROVIDER: S-EPMC8451266 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature