Prognostic significance of OX40⁺ lymphocytes in tumor stroma of surgically resected small-cell lung cancer.

ABSTRACT: OX40 (CD134) is a co-stimulatory molecule mostly expressed on activated T lymphocytes. Previous reports have shown that OX40 can be an immuno-oncology target and a clinical biomarker for cancers of various organs. In this study, we collected formalin-fixed paraffin-embedded tumor samples from 124 patients with small-cell lung cancer (SCLC) who had undergone surgery. We analyzed the expression profiles of OX40 and other relevant molecules, such as CD4, CD8, and Foxp3, in tumor stroma and cancer nest using immunohistochemistry and investigated their association with survival. High infiltration of OX40⁺ lymphocytes (OX40^high) in tumor stroma was positively associated with relapse-free survival (RFS) and overall survival (OS) compared with low infiltration of OX40^+</

SUBMITTER: Yokouchi H 

PROVIDER: S-EPMC8451465 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature