Importance of twitching and surface-associated motility in the virulence of Acinetobacter baumannii.

ABSTRACT: Acinetobacter baumannii is a pathogen of increasing clinical importance worldwide, especially given its ability to readily acquire resistance determinants. Motile strains of this bacterium can move by either or both of two types of motility: (i) twitching, driven by type IV pili, and (ii) surface-associated motility, an appendage-independent form of movement. A. baumannii strain MAR002 possesses both twitching and surface-associated motility. In this study, we isolated spontaneous rifampin-resistant mutants of strain MAR002 in which point mutations in the rpoB gene were identified that resulted in an altered motility pattern. Transcriptomic analysis of mutants lacking twitching, surface-associated motility, or both led to the identification of deregulated genes within

SUBMITTER: Corral J 

PROVIDER: S-EPMC8451467 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature