Dendritic spine density changes and homeostatic synaptic scaling: a meta-analysis of animal studies.

ABSTRACT: Mechanisms of homeostatic plasticity promote compensatory changes of cellular excitability in response to chronic changes in the network activity. This type of plasticity is essential for the maintenance of brain circuits and is involved in the regulation of neural regeneration and the progress of neurodegenerative disorders. One of the most studied homeostatic processes is synaptic scaling, where global synaptic adjustments take place to restore the neuronal firing rate to a physiological range by the modulation of synaptic receptors, neurotransmitters, and morphology. However, despite the comprehensive literature on the electrophysiological properties of homeostatic scaling, less is known about the structural adjustments that occur in the synapses and dendritic tree. In this study, we pe

SUBMITTER: Moulin TC 

PROVIDER: S-EPMC8451564 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature