New perspectives for mesenchymal stromal cells as an adjuvant therapy for infectious disease-associated encephalopathies.

ABSTRACT: Knowledge of the mechanisms that trigger infection-related encephalopathies is still very limited and cell therapies are one of the most promising alternatives for neurodegenerative diseases, and its application in infectious diseases can be of great relevance. Mesenchymal stromal cells are cells with great immunomodulatory potential; therefore, their use in clinical and preclinical studies in a variety of diseases, including central nervous system diseases, increased in the last decade. Mesenchymal stromal cells can exert their beneficial effects through several mechanisms, such as direct cell contact, through surface receptors, and also through paracrine or endocrine mechanisms. The paracrine mechanism is widely accepted by the scientific community and involves the release of soluble fac

SUBMITTER: Lima MN 

PROVIDER: S-EPMC8451575 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature