Comparative effectiveness and safety of direct oral anticoagulants versus warfarin in UK patients with atrial fibrillation and type 2 diabetes: A retrospective cohort study.

ABSTRACT:

Purpose

To estimate the effectiveness and safety of direct oral anticoagulants (DOACs) compared with warfarin in AF patients with type 2 diabetes (T2DM).

Methods

A retrospective cohort study was designed, using the UK Clinical Practice Research Datalink (August 2011-June 2018). Participants were 1-year naïve users of DOACs or warfarin, followed from the date of first prescription of an oral anticoagulant until the end of the study period, death, discontinuation of treatment, switching to another anticoagulant, or an outcome of interest, whichever came first. Cox regression analysis was performed to estimate the hazard ratio (HR) adjusted for potential confounders.

Results

A total of 8555 patients were identified. No significant differences were found between DOACs and

SUBMITTER: Rustem Gulluoglu F 

PROVIDER: S-EPMC8451809 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature