Early exposure of pregnant women to non-steroidal anti-inflammatory drugs delivered outside hospitals and preterm birth risk: nationwide cohort study.

ABSTRACT:

Objective

To assess the risk of preterm birth associated with nonsteroidal anti-inflammatory drugs (NSAIDs), focusing on early exposure in the period from conception to 22 weeks of gestation (WG).

Design

National population-based retrospective cohort study.

Setting

The French National Health Insurance Database that includes hospital discharge data and health claims data.

Population

Singleton pregnancies (2012-2014) with a live birth occurring after 22WG from women between 15 and 45 years old and insured the year before the first day of gestation and during pregnancy were included. We excluded pregnancies for which anti-inflammatory medications were dispensed after 22WG.

Methods

The association between exposure and risk of preterm birth was evaluated with

SUBMITTER: Quantin C 

PROVIDER: S-EPMC8451913 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature