Chondrocyte-to-osteoblast transformation in mandibular fracture repair.

ABSTRACT: The majority of fracture research has been conducted using long bone fracture models, with significantly less research into the mechanisms driving craniofacial repair. However, craniofacial bones differ from long bones in both their developmental mechanism and embryonic origin. Thus, it is possible that their healing mechanisms could differ. In this study we utilize stabilized and unstabilized mandible fracture models to investigate the pathways regulating repair. Whereas fully stable trephine defects in the ramus form bone directly, mechanical motion within a transverse fracture across the same anatomical location promoted robust cartilage formation before boney remodeling. Literature investigating long bone fractures show chondrocytes are a direct precursor of osteoblasts during endochon

SUBMITTER: Wong SA 

PROVIDER: S-EPMC8451921 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature