Impact of anticoagulant exposure misclassification on the bleeding risk of direct oral anticoagulants.

ABSTRACT:

Aims

Drug exposure status based on routinely collected data might be misclassified when the database contains only prescriptions from 1 type of prescriber (e.g. general practitioner and not specialist). This study aims to quantify the impact of such exposure misclassification on the risk of major bleeding and stroke/transient ischaemic attack (TIA)associated with direct oral anticoagulants (DOACs) vs. vitamin K antagonists (VKAs).

Methods

Incident anticoagulant users (>12 mo free of anticoagulation use) in the Dutch PHARMO Database Network between 2008 and 2017 were included. Drug exposure was assessed using pharmacy dispensing information. The risks of hospital admission of major bleeding for DOAC vs. VKA users was assessed with Cox regression analysis, where exposure was b

SUBMITTER: Hempenius M 

PROVIDER: S-EPMC8451929 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature