The regulation landscape of MAPK signaling cascade for thwarting Bacillus thuringiensis infection in an insect host.

ABSTRACT: Host-pathogen interactions are central components of ecological networks where the MAPK signaling pathways act as central hubs of these complex interactions. We have previously shown that an insect hormone modulated MAPK signaling cascade participates as a general switch to trans-regulate differential expression of diverse midgut genes in the diamondback moth, Plutella xylostella (L.) to cope with the insecticidal action of Cry1Ac toxin, produced by the entomopathogenic bacterium Bacillus thuringiensis (Bt). The relationship between topology and functions of this four-tiered phosphorylation signaling cascade, however, is an uncharted territory. Here, we carried out a genome-wide characterization of all the MAPK orthologs in P. xylostella to define their phylogenetic relationships and to co

SUBMITTER: Guo Z 

PROVIDER: S-EPMC8452011 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature