Current Landscape of Immunotherapy in Breast Cancer: A Review.

ABSTRACT:

Importance

There is tremendous interest in using immunotherapy to treat breast cancer, as evidenced by the more than 290 clinical trials ongoing at the time of this narrative review. The objective of this review is to describe the current status of immunotherapy in breast cancer, highlighting its potential in both early-stage and metastatic disease.

Observations

After searching ClinicalTrials.gov on April 24, 2018, and PubMed up to June 30, 2018, to identify breast cancer immunotherapy trials, we found that immune checkpoint blockade (ICB) is the most investigated form of immunotherapy in breast cancer. Use of ICB as monotherapy has achieved objective responses in patients with breast cancer, with higher rates seen when administered in earlier lines of therapy. For respondin

SUBMITTER: Adams S 

PROVIDER: S-EPMC8452050 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature