Use of metoclopramide in the first trimester and risk of major congenital malformations: A systematic review and meta-analysis.

ABSTRACT:

Background

Nausea and vomiting of pregnancy affects up to 80% of pregnant women, it typically occurs during the first trimester which is the most sensitive time for environmental exposures given organogenesis. Metoclopramide is an antiemetic drug used widely during NVP, but the findings of studies evaluating its safety of use in pregnancy is inconsistent. Therefore, we conducted a systematic review and meta-analysis to assess whether metoclopramide use during first trimester of pregnancy is associated with the risk of major congenital malformations.

Methods

The systematic search using database included Pubmed, Embase, Web of science, and Cochrane library. Studies written in English, comprising with an exposed group and a control group, reporting major congenital malformation

SUBMITTER: Sun L 

PROVIDER: S-EPMC8452057 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature