Assessment of small-intestine permeability in healthy Nigerian children is altered by urinary volume and voiding status.

ABSTRACT:

Objective

This study aimed to uncover the effect of voided urinary volume on small intestine permeability ratios in healthy children.

Methods

We assessed small intestine permeability in 155 apparently healthy children, aged 3-5 years old, without any visible symptoms of disease, in a rural, malaria-endemic setting in Nigeria, using a multi-sugar test solution, comprising lactulose, sucrose, mannitol, and rhamnose. Children were categorized into low urinary volume (LV) and high urinary volume (HV), based on the volume of urine voided per kg body weight per hour. LV children voided less than 25th percentile of the total population, while HV children voided greater than 75th percentile of the total population. Urinary volume excreted over a 90-minute period after administration

SUBMITTER: Afolami I 

PROVIDER: S-EPMC8452060 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature