Long-Term Intrahost Evolution of Staphylococcus aureus Among Diabetic Patients With Foot Infections.

ABSTRACT: Staphylococcus aureus is one of the main pathogens isolated from diabetic foot infections (DFI). The purpose of this study was to evaluate the importance of the persistence of S. aureus in this environment and the possible modifications of the bacterial genome content over time. Molecular typing of S. aureus isolates cultured from patients with the same DFI over a 7-year study revealed a 25% rate of persistence of this species in 48 patients, with a short median persistence time of 12weeks (range: 4-52weeks). Non-specific clonal complexes were linked to this persistence. During the follow-up, bla genes were acquired in three cases, whereas some virulence markers were lost in all cases after a long period of colonization (21.5weeks). Only one patient (2%) had a l

SUBMITTER: Lavigne JP 

PROVIDER: S-EPMC8452158 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature