Intra-operative open-lung ventilatory strategy reduces postoperative complications after laparoscopic colorectal cancer resection: A randomised controlled trial.

ABSTRACT:

Background

The role of the positive end-expiratory pressure (PEEP) and lung recruitment manoeuvre (LRM) combination (termed open-lung strategy, OLS) during intra-operative mechanical ventilation is not clear.

Objective

To determine whether an open-lung strategy constituting medium PEEP (6-8 cmH2O) and repeated LRMs protects against postoperative complications in at-risk patients undergoing laparoscopic colorectal cancer resection under low-tidal-volume ventilation.

Design

A prospective, assessor-blinded, randomised controlled trial.

Setting

Single university-affiliated hospital, conducted from January 2017 to October 2018.

Patients

A total of 280 patients at risk of pulmonary complications, scheduled for laparoscopic colorectal cancer resection under gen

SUBMITTER: Li H 

PROVIDER: S-EPMC8452317 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature