Prediction of tumor response via a pretreatment MRI radiomics-based nomogram in HCC treated with TACE.

ABSTRACT:

Objectives

To develop and validate a pre-transcatheter arterial chemoembolization (TACE) MRI-based radiomics model for predicting tumor response in intermediate-advanced hepatocellular carcinoma (HCC) patients.

Materials

Ninety-nine intermediate-advanced HCC patients (69 for training, 30 for validation) treated with TACE were enrolled. MRI examinations were performed before TACE, and the efficacy was evaluated according to the mRECIST criterion 3 months after TACE. A total of 396 radiomics features were extracted from T2-weighted pre-TACE images, and least absolute shrinkage and selection operator (LASSO) regression was applied to feature selection and model construction. The performance of the model was evaluated by receiver operating characteristic (ROC) curves, calibratio

SUBMITTER: Kong C 

PROVIDER: S-EPMC8452577 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature