Retinal and choroidal thickness changes in systemic lupus erythematosus patients: a longitudinal study.

ABSTRACT:

Background/objectives

To prospectively evaluate changes in peripapillary retinal nerve fibre layer (pRNFL), in all macular layers and in choroidal thickness (CT) in a cohort of systemic lupus erythematosus (SLE) patients without ophthalmologic manifestations. To associate those changes with ophthalmic characteristics, disease activity state, medication and systemic comorbidities.

Subjects/methods

Prospective cohort study of 68 previously diagnosed SLE patients. In two study visits (V1 and V2) at least 12 months apart, patients underwent a complete ophthalmologic examination including spectral domain-optical coherence tomography (SD-OCT) and an autoimmune disease specialist assessment. Automatic retinal segmentation was performed. pRNFL was determined globally and in the six

SUBMITTER: Dias-Santos A 

PROVIDER: S-EPMC8452661 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature