Oncogenic signaling inhibits c-FLIP_L expression and its non-apoptotic function during ECM-detachment.

ABSTRACT: Inhibition of programmed cell death pathways is frequently observed in cancer cells where it functions to facilitate tumor progression. However, some proteins involved in the regulation of cell death function dichotomously to both promote and inhibit cell death depending on the cellular context. As such, understanding how cell death proteins are regulated in a context-dependent fashion in cancer cells is of utmost importance. We have uncovered evidence that cellular FLICE-like Inhibitory Protein (c-FLIP), a well-known anti-apoptotic protein, is often downregulated in tumor tissue when compared to adjacent normal tissue. These data argue that c-FLIP may have activity distinct from its canonical role in antagonizing cell death. Interestingly, we have discovered that detachment from extracell

SUBMITTER: Tsegaye MA 

PROVIDER: S-EPMC8452765 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature